A variety of herbicides act by inhibiting the branched chain amino‐acid biosynthetic enzyme, acetolactate synthase (EC 4.1.3.18). The initial consequences of this event are 2‐ketoacid accumulation and amino‐acid starvation. Recent studies demonstrate that 2‐ketoacid imbalances play a significant role in the action of these herbicides; such imbalances may also be important in certain inborn errors of human metabolism.

The view that it is better for life to be created free of disability is pervasive in both common sense and philosophy. We cast doubt on this view by focusing on an influential line of thinking that manifests it. That thinking begins with a widely-discussed principle, Procreative Beneficence, and draws conclusions about parental choice and disability. After reconstructing two versions of this argument, we critique the first by exploring the relationship between different understandings of well-being and disability, and the second (...) by more briefly focusing on the idea of a significant reason. By placing these results against the broader historical and ongoing contexts in which the lives of those with disabilities have been deemed of inferior quality, we conclude with a call for greater humility about disability and well-being in thought and practice. (shrink)

Growing interest in workplace spirituality has led to the development of a new paradigm in organizational science. Theoretical assumptions abound as to how workplace spirituality might enhance organizational performance, most postulating a significant positive impact. Here, that body of research has been reviewed and analyzed, and a resultant values framework for workplace spirituality is introduced, providing the groundwork for empirical testing. A discussion of the factors and assumptions involved for future research are outlined.

Sexual behaviour and mate choice are key intervening variables between attachment and life histories. We propose a set of predictions relating attachment, reproductive strategies, and mate choice criteria.

A poetic study of a singular form of urban industrial art and its place in American culture. They lie underfoot, embellished and gleaming. They seal off and provide entry to an underground world of conduits, water mains, power lines, and sewers. They appear by the thousands in our cities, but very few people ever look at them or think about them as art. At once completely ordinary and totally unexpected, manhole covers present an infinite variety of design in the commonplace (...) as well as a record of defunct utility companies, forgotten business firms, and obsolete foundries. Manhole Covers documents this singular form of urban industrial art and its place in American culture. Mimi and Robert Melnick first revealed their obsession with street hardware twenty years ago in a remarkable little book called Manhole Covers of Los Angeles. Printed in a small format and a limited edition, it quickly went out of print and is now a scarce collector's item. But that was just an introduction to their larger project, which has come to fruition in this book of 200 photographs and an extended narrative documenting manhole covers throughout the United States and discussing the history of their use, manufacture, and function. A subject that at first seems straightforward and commonplace becomes redolent and poetic in the Melnicks' hands, for their hieroglyphic reading of manhole covers reveals a chapter of urban history that can only be recovered from the logos and markings of these early disks. There are square lids, convex lids, perforated lids. And the older ones wear an astonishingly diverse range of anything-but-blank faces expressed in raised crosses, waffle grids, cut-out diamonds, radial stars, floral patterns, and honeycomb treads. The diversity of design corresponds to an equally diverse typology of form and function, as indicated by their evocative labels: handholes, vents, coalholes, grates, lampholes, storm drains, steam covers, meter lids, traffic buttons. (shrink)

The concept of anxiety has long held a central place in psychoanalytic theories of mind and treatment. Yet, in recent years, data from the neurosciences and from pharmacological studies have posed a compelling challenge to psychoanalytic models of anxiety. One major outcome of these studies is the realization that anxiety both organizes and disorganizes, that it can be both symptom and signal. In _Anxiety as Symptom and Signal_, editors Steven Roose and Robert Glick have brought together distinguished contributors to (...) address these different dimensions of anxiety. A section of original papers on "Anxiety as Symptom" covers evolutionary, neuroanatomical, genetic, and developmental perspectives. A complementary section on "Anxiety as Signal" focuses on the meanings and functions of anxiety in the clinical process; contributions address anxiety in its ego-psychological, intersubjective, and relational dimensions. The illuminating, readable collection will broaden clinicians' awareness of the diverse research findings that now inform our understanding of anxiety. No less importantly, it will deepen their appreciation of the richly variegated ways that anxiety can shape, and be shaped by, the clinical process. (shrink)

The concept of anxiety has long held a central place in psychoanalytic theories of mind and treatment. Yet, in recent years, data from the neurosciences and from pharmacological studies have posed a compelling challenge to psychoanalytic models of anxiety. One major outcome of these studies is the realization that anxiety both organizes and disorganizes, that it can be both symptom and signal. In _Anxiety as Symptom and Signal_, editors Steven Roose and Robert Glick have brought together distinguished contributors to (...) address these different dimensions of anxiety. A section of original papers on "Anxiety as Symptom" covers evolutionary, neuroanatomical, genetic, and developmental perspectives. A complementary section on "Anxiety as Signal" focuses on the meanings and functions of anxiety in the clinical process; contributions address anxiety in its ego-psychological, intersubjective, and relational dimensions. The illuminating, readable collection will broaden clinicians' awareness of the diverse research findings that now inform our understanding of anxiety. No less importantly, it will deepen their appreciation of the richly variegated ways that anxiety can shape, and be shaped by, the clinical process. (shrink)

Where does the mind begin and end? Most philosophers and cognitive scientists take the view that the mind is bounded by the skull or skin of the individual. Robert Wilson, in this provocative and challenging 2004 book, provides the foundations for the view that the mind extends beyond the boundary of the individual. The approach adopted offers a unique blend of traditional philosophical analysis, cognitive science, and the history of psychology and the human sciences. The companion volume, Genes and (...) the Agents of Life, explores the theme in the biological sciences. Written with verve and clarity, this ambitious book will appeal to a broad swathe of professionals and students in philosophy, psychology, cognitive science, and the history of the behavioural and human sciences. You can download the table of contents here. (shrink)

Stakeholder theory has become a central issue in the literature on business ethics / business and society. There are, however, a number of problems with stakeholder theory as currently understood. Among these are: 1) the lack of a coherent justificatory framework, 2) the problem of adjudicating between stakeholders, and 3) the problem of stakeholder identification. In this essay, I propose that a possible source of obligations to stakeholders is the principle of fairness (or fair play) as discussed in the political (...) philosophic literature of Rawls, Simmons, and Cullity among others. The principle of fairness states that, “Whenever persons or groups of persons voluntarily accept the benefits of a mutually beneficial scheme of co-operation requiring sacrifice or contribution on the parts of the participants and there exists the possibility of free-riding, there exist obligations of fairness on the part of these persons or groups to co-operate in proportion to the benefits accepted.” In this essay I discuss the gaps in the current stakeholder literature, elucidate and defend a principle of fairness that fills the gap, compare the fairness model to other similar models of business ethics, and draw some conclusions for the future of stakeholder theory. (shrink)

Contemporary commentators on Hume's essay, ‘Of miracles’ have increasingly tended to argue that Hume never intended to suggest that testimonial evidence must always be insufficient to justify belief in a miracle. This is in marked contrast to earlier commentators who interpreted Hume as intending to demonstrate that testimonial evidence is incapable in principle of ever establishing rational belief in a miracle. In this article I argue that this traditional interpretation is the correct one.

This is a critical response to "Defending Eugenics", published in MBR in 2018.

In Anselm's Discovery , Professor Hartshorne makes the rather startling and counterintuitive claim that ‘…there is indeed no issue between theism and pantheism. We all exist in the divine being, as St Paul said.’ 1 Classical or orthodox theists, it seems eminently fair to say, can be expected to recoil from any such suggestion with more than a little indignation. First of all, it might well be objected that Hartshorne - as a ‘process theist’ - is not a classical theist, (...) and, consequently, while there may be no issue between pantheism and his brand of theism, such is simply not the case in so far as classical theism is concerned. According to the latter - in contradistinction, of course, to Hartshorne's ‘neoclassical theism’ - immutability is an ‘essential’ property of God; as such, it would be a conceptual error to ascribe any contingent states to God at all. Now as is well known by philosophers of religion, Hartshorne regards this immutability doctrine of classical theism as a serious ‘logical blunder’ , one which - in so far as it reflects the ‘Greek bias’ which has always identified perfection with the absolutely unchangeable - is profoundly distortive of the biblical concept of Deity. (shrink)

1. The Situation in Cognition 2. Situated Cognition: A Potted Recent History 3. Extensions in Biology, Computation, and Cognition 4. Articulating the Idea of Cognitive Extension 5. Are Some Resources Intrinsically Non-Cognitive? 6. Is Cognition Extended or Only Embedded? 7. Letting Nature Take Its Course.

Genes and the Agents of Life undertakes to rethink the place of the individual in the biological sciences, drawing parallels with the cognitive and social sciences. Genes, organisms, and species are all agents of life but how are each of these conceptualized within genetics, developmental biology, evolutionary biology, and systematics? The 2005 book includes highly accessible discussions of genetic encoding, species and natural kinds, and pluralism above the levels of selection, drawing on work from across the biological sciences. The book (...) is a companion to the author's Boundaries of the Mind (2004), also available from Cambridge, where the focus is the cognitive sciences. The book will appeal to a broad range of professionals and students in philosophy, biology, and the history of science. You can download the table of contents and the first chapter here. (shrink)

This is an introductory article on sociobiology, particularly its relationship to eugenics. Sociobiology developed in the 1960s as a field within evolutionary biology to explain human social traits and behaviours. Although sociobiology has few direct connections to eugenics, it shares eugenics’ optimistic enthusiasm for extending biological science into the human domain, often with reckless sensationalism. Sociobiology's critics have argued that sociobiology also propagates a kind of genetic determinism and represents the zealous misapplication of science beyond its proper reach that characterized (...) the eugenics movement. More recently, evolutionary psychology represents a sophistication of sociobiology that attends to the mind as the "missing link" between evolution and behaviour (Cosmides and Tooby 1992, Pinker 1997). (shrink)

Although ethics consultation is offered as a clinical service in most hospitals in the United States, few valid and practical tools are available to evaluate, ensure, and improve ethics consultation quality. The quality of ethics consultation is important because poor quality ethics consultation can result in ethically inappropriate outcomes for patients, other stakeholders, or the health care system. To promote accountability for the quality of ethics consultation, we developed the Ethics Consultation Quality Assessment Tool. ECQAT enables raters to assess the (...) quality of ethics consultations based on the written record. Through rigorous development and preliminary testing, we identified key elements of a quality ethics consultation, established scoring criteria, developed training guidelines, and designed a holistic assessment process. This article describes the development of the ECQAT,.. (shrink)

I am grateful to Philip Quinn for his thorough and penetrating critique of my paper on classical theism and pantheism. He has given me much to think about, and it would be philosophically remiss of me not to acknowledge that – in the light of his remarks – the argument which I employed in defence of the thesis that classical theism implies a version of pantheism might well benefit from some amendment. However, the purpose of this brief counter-rejoinder is to (...) establish that the nexus of my argument has emerged from his commentary in reasonably robust health, i.e., to demonstrate that if the argument of my former paper is to be rejected, it will take something more than Professor Quinn's critique to make that clear. Very concisely, then, my response is as follows: At a preliminary point, Professor Quinn claims that my argument ‘merits careful scrutiny’ because, if it succeeds, ‘something shockingly at variance with received views’ will have been established . I find this to be somewhat odd. For it seems clear that St Paul was a ‘classical theist’, indeed a very special one in so far as the shaping of Christian theism is concerned. And while his famous and oftcited dictum that God is the One in Whom ‘we live, move, and have our being’ may be such that it is permissible to construe it in ways which do not imply any version of pantheism, it clearly seems unjustified to maintain that pantheistic doctrines are ‘shockingly at variance’ with that most intriguing statement of St Paul's. (shrink)

The purpose of this paper is to clear up the long-standing veritable mountain of misinterpretation, perpetuated from critic to critic, concerning the admittedly problematic concept of self-authenticating religious experience. While it may well be the case, as many have argued, that a sort of ‘experience’ about which one could not be mistaken is simply a logically impossible state of affairs, this cannot be known to be the case so long as what is under attack is a bogus concept, obviously absurd, (...) having nothing whatsoever to do with the correct interpretation of ‘self-authentication’. Hence, my mission herein is essentially that of philosophical analysis or clarification of meaning. Only upon suitable clarification of this concept will we be in a position to consider the question of its possible application, i.e. whether or not there could be an instantiation of such experience. I might point out that my central concern is somewhat more explicatory than historical, though I believe that the account developed in this paper is essentially congenial with the intent of those who have been proponents of the view that there can be self-authenticating religious experience. Let us begin, then, by turning to some representative criticism of the concept in question. (shrink)

In his paper ‘Miracles: metaphysics, physics, and physicalism’, 1 Kirk McDermid appears to have two primary goals. The first is to demonstrate that my account of how God might produce a miracle without violating any laws of nature is radically flawed. The second is to suggest two alternative accounts, one suitable for a deterministic world, one suitable for an indeterministic world, which allow for the occurrence of a miracle without violation of the laws of nature, yet do not suffer from (...) the defects of what McDermid terms the ‘Larmerian’ model. I briefly describe my model, reply to McDermid's criticism of it, and evaluate his alternative accounts. (shrink)

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

This paper explores the relationship between eugenics, disability, and dehumanization, with a focus on forms of eugenics beyond Nazi eugenics.

The computational argument for individualism, which moves from computationalism to individualism about the mind, is problematic, not because computationalism is false, but because computational psychology is, at least sometimes, wide. The paper provides an early, or perhaps predecessor, version of the thesis of extended cognition.

The Eugenic Mind Project is a wide-ranging, philosophical book that explores and critiques both past and present eugenic thinking, drawing on the author’s intimate knowledge of eugenics in North America and his previous work on the cognitive, biological, and social sciences, the fragile sciences. Informed by the perspectives of Canadian eugenics survivors in the province of Alberta, The Eugenic Mind Project recounts the history of eugenics and the thinking that drove it, and critically engages contemporary manifestations of eugenic thought, newgenics. (...) An accessible, original work of scholarship adopting what the author calls a standpoint eugenics, this book focuses on the roots of eugenic thinking past and present. It will provoke and enrich discussions about human nature and human diversity, the social uses of biotechnology, and social policy governing future generations. You can download the preface and acknowledgements here. (shrink)

Eugenics does not feel so distant from where I stand. This essay explains why.

Stakeholder theory is often unable to distinguish those individuals and groups that are stakeholders from those that are not. This problem of stakeholder identity has recently been addressed by linking stakeholder theory to a Rawlsian principle of fairness. To illustrate, the question of stakeholder status for the non-human environment is discussed. This essay criticizes a past attempt to ascribe stakeholder status to the non-human environment, which utilized a broad definition of the term "stakeholder." This paper then demonstrates how, despite the (...) denial of stakeholder status, the environment is nonetheless accounted for on a fairness-based approach through legitimate organizational stakeholders. In addition, since stakeholder theory has never claimed to be a comprehensive ethical scheme, it is argued that sound reasons might exist for managers to consider their organization's impact on the environment that are not stakeholder-related. (shrink)

This volume of twelve specially commissioned essays about species draws on the perspectives of prominent researchers from anthropology , botany, developmental psychology , the philosophy of biology and science, protozoology, and zoology . The concept of species has played a focal role in both evolutionary biology and the philosophy of biology , and the last decade has seen something of a publication boom on the topic (e.g., Otte and Endler 1989; Ereshefsky 1992b; Paterson 1994; lambert and Spence 1995; Claridge, Dawah, (...) and Wilson 1997; Wheeler and Meier 1999; Howard and Berlocher 1998). (shrink)

This paper considers recent heated debates led by Jerry A. Coyne andMichael J. Wade on issues stemming from the 1929–1962 R.A. Fisher-Sewall Wrightcontroversy in population genetics. William B. Provine once remarked that theFisher-Wright controversy is central, fundamental, and very influential.Indeed,it is also persistent. The argumentative structure of therecent (1997–2000) debates is analyzed with the aim of eliminating a logicalconflict in them, viz., that the two sides in the debates havedifferent aims and that, as such, they are talking past each other. (...) Given aphilosophical analysis of the argumentative structure of the debates,suggestions supportive of Wade's work on the debate are made that areaimed, modestly, at putting the persistent Fisher-Wright controversy on thecourse to resolution. (shrink)

Are materially constituted entities, such as statues and glasses of liquid, something more than their material constituents? The puzzle that frames this paper stems from conflicting answers to this question. At the core of the paper is a distinctive way of thinking about material constitution that posits two concepts of constitution, compositional and ampliative constitution, with the bulk of the discussion devoted to developing distinct analyses for these concepts. Distinguishing these concepts solves our initial puzzle and enriches the space of (...) possibilities for constitution views. (shrink)

While memory is conceptualized predominantly as an individual capacity in the cognitive and biological sciences, the social sciences have most commonly construed memory as a collective phenomenon. Collective memory has been put to diverse uses, ranging from accounts of nationalism in history and political science to views of ritualization and commemoration in anthropology and sociology. These appeals to collective memory share the idea that memory ‘‘goes beyond the individual’’ but often run together quite different claims in spelling out that idea. (...) This paper reviews a sampling of recent work on collective memory in the light of emerging externalist views within the cognitive sciences, and through some reflection on broader traditions of thought in the biological and social sciences that have appealed to the idea that groups have minds. The paper concludes with some thoughts about the relationship between these kinds of cognitive metaphors in the social sciences and our notion of agency. (shrink)

The Westermarck Effect posits that intimate association during childhood promotes human incest avoidance. In previous work, I articulated and defended a version of the Westermarck Effect by developing a phylogenetic argument that has purchase within primatology but that has had more limited appeal for cultural anthropologists due to their commitment to conventionalist or culture-first accounts of incest avoidance. Here I look to advance the discussion of incest and incest avoidance beyond culture-first accounts in two ways. First, I shall dig deeper (...) into the disciplinary grooves within cultural anthropology that make attractive the view that incest has a naturalness to it that is countered only or primarily by explicit social rules, such as taboos. Second, I further explore the emerging, post-conventionalist view of incest avoidance in a more positive vein by elaborating on the nature of the Westermarckian mechanism and how it relates to such explicit social rules and our innate biological endowments. One general aim here is to overcome the bifurcation between perspectives that are seen as biological and those seen as cultural, preempting or countering the claim that rejecting culture-first accounts entails a form of biological reductionism, a general aim I have pursued in related publications on bioessentialism about kinship. (shrink)

Who is recognised as a philosopher and what counts as philosophy influence both the content of a philosophical education and academic philosophy’s continuing demographic skew. The “philosophical who” and the “philosophical what” themselves are a partial function of matters that have been passed over in collective silence, even if that now feels to some like a silence belonging to the distant past. This paper discusses some philosophical silences regarding race, gender, and disability in the context of reflection on philosophical education (...) and on philosophical practice in the public sphere. It focuses on Charles Mills’ writings on race, Susan Babbitt’s on race and gender, and on more collaboratively-generated work on eugenics and disability. (shrink)

This book offers a sustained critique of individualism in psychology, a view that has been the subject of debate between philosophers such as Jerry Fodor and Tyler Burge for many years. The author approaches individualism as an issue in the philosophy of science and by discussing issues such as computationalism and the mind's modularity he opens the subject up for non-philosophers in psychology and computer science. Professor Wilson carefully examines the most influential arguments for individualism and identifies the main metaphysical (...) assumptions underlying them. Since the topic is so central to the philosophy of mind, a discipline generating enormous research and debate, the book has implications for a very broad range of philosophical issues including the naturalisation of intentionality, psychophysical supervenience, the nature of mental causation, and the viability of folk psychology. (shrink)

This paper examines the standard view of realization operative incontemporary philosophy of mind, and proposes an alternative, generalperspective on realization. The standard view can be expressed, insummary form, as the conjunction of two theses, the sufficiency thesis andthe constitutivity thesis. Physicalists of both reductionist and anti-reductionist persuasions share a conception of realization wherebyrealizations are determinative of the properties they realize and physically constitutive of the individuals with those properties. Centralto the alternative view that I explore here is the idea that (...) the requisite,metaphysically robust notion of realization is ineliminably context-sensitive. I shall argue that the sufficiency and constitutivity theses aretypically not jointly satisfied by any one candidate realizer, and that goingcontext-sensitive in one's metaphysics is preferable to the standard view.The context-sensitive views developed here are implicit in a range ofcommon views in both the philosophy of mind and the philosophy of biology,even if they have not been explicitly articulated, and even though theyundermine other views that are commonly endorsed. (shrink)

Dominant views of personal identity in philosophy take some kind of psychological continuity or connectedness over time to be criterial for the identity of a person over time. Such views assign psychological states, particularly those necessary for narrative memory of some kind, special importance in thinking about the nature of persons. The extended mind thesis, which has generated much recent discussion in the philosophy of mind and cognitive science, holds that a person’s psychological states can physically extend beyond that person’s (...) body. Since “person” is a term of both metaphysical and moral significance, and discussions of both extended minds and personal identity have often focused on memory, this article explores the relevance of extended cognition for the identity of persons with special attention to neuroethics and memory. (shrink)

In Water into Wine? Robert Larmer re-examines significant issues in this cross-disciplinary debate and attacks two basic assumptions governing it.